BASE-CATALYZED DEUTERIUM EXCHANGE WITH DIPHOSPHOPYRIDINE NUCLEOTIDE
نویسندگان
چکیده
منابع مشابه
The preparation of diphosphopyridine nucleotide with ion exchange resin.
The older methods for the preparation of diphosphopyridine nucleotide (DPN) were reviewed in 1942 by Schlenk (1). In 1947 Sumner et al. (2) outlined the need for a greatly simplified method for the preparation of this coenzyme. These authors described a procedure which did away with heavy metal fractionation. Recently, Clark et al. (3) made several modifications in the above method. The LePage ...
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Enzymatic splitting of diphosphopyridine nucleotide (DPN)’ by microorganisms, plants, and animal tissues has been known for many years, but the precise nature of this reaction is not well understood (1). Ohlmeyer (2) first observed that adenylic acid (5-phosphoadenosine) appeared when DPN was incubated with yeast maceration juice. Later Heiwinkel (3) identified adenylic acid as a product of the...
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It has been previously shown (l-3) that the nicotinamide moiety of diphosphopyridine nucleotide can be replaced by other pyridine bases without the loss of the coenzyme function. The observation that both the 3-acetylpyridine and pyridine-3aldehyde analogues of diphosphopyridine nucleotide function as coensymes with various dehydrogenases (3) indicated that the amide group on DPN was not essent...
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The need for additional study on the specific relation between metallic ions and metabolic function, especially in the case of the diphosphopyridine nucleotide oxidase system, has been expressed by Mahler (1) and others. This is particularly indicated in view of the fact that a number of the known components of this system contain iron. While it is broadly concluded that iron compounds facilita...
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In continuation of our investigation of liver diphosphopyridine nucleotide-linked aldehyde dehydrogenase (1)) we have undertaken a study of various classes of inhibitors of the enzyme. Interest in aldehyde oxidation has been increasing in recent years from several points of view. The classical problem of ethanol oxidation in viva still has many unresolved facets (Z), and the enzymes responsible...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1955
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)65923-x